By merging Ayurveda and advanced pharmaceutical technology, scientists develop a next-generation Tulsi preparation aimed at cancer prevention and oxidative stress reduction
A team of Indian researchers has developed a novel ultrasonic-assisted formulation of Tulsi (Ocimum sanctum) that shows strong potential in the chemoprevention of breast cancer through antioxidant and anti-inflammatory mechanisms. This innovation represents a significant step in modernizing Ayurvedic medicine by combining traditional herbal wisdom with advanced pharmaceutical technology.
The formulation was developed by Dr. Pravin Badhe, Mrs. Ashwini Badhe, Merin Levy Philips, Dr. Santhosha Kulal, Dr. Yashodha Darshan, Dr. Vastvikta Sahai, and Dr. Sanjana A, with expertise spanning pharmacy, pharmacology, and phytopharmaceutical sciences. Their work focuses on refining Tulsi, one of India’s most revered medicinal plants, into a scientifically standardized oral suspension with improved bioavailability, stability, and therapeutic consistency.
Modern Extraction for a Traditional Herb
At the core of this innovation is Ultrasonic-Assisted Extraction (UAE), which uses high-frequency sound waves to efficiently extract active compounds from Tulsi leaves. Conducted at 50 kHz and 40 °C for 50 minutes in 95% ethanol, the process ensures maximum recovery of key phytoconstituents such as eugenol, ursolic acid, apigenin, and rosmarinic acid.
Unlike conventional methods that can degrade delicate bioactives, UAE preserves their structure and potency. The extract is formulated into a stable oral suspension with Tween 80 (1%), sodium carboxymethyl cellulose (1%), and sodium benzoate (0.1%), providing uniform dispersion, microbial protection, and long shelf life. This results in a pharmaceutically stable herbal formulation that overcomes issues like sedimentation, poor solubility, and degradation.
Chemopreventive Potential Through Antioxidant and TNF-α Modulation
Laboratory studies show that the Tulsi formulation exhibits strong antioxidant and anti-inflammatory activity, both crucial for preventing cellular damage and disease progression. It reduces lipid peroxidation (MDA) levels while boosting natural antioxidant defenses such as glutathione (GSH) and superoxide dismutase (SOD).
The formulation also regulates tumor necrosis factor-alpha (TNF-α), a key inflammatory mediator linked to cancer development. By targeting both oxidative stress and inflammatory pathways, it demonstrates strong potential for chemopreventive use, particularly in breast cancer and other oxidative disorders.
Safety studies confirm that the suspension is non-toxic, well tolerated, and compliant with international standards positioning it as a safe, stable, and effective phytopharmaceutical for long-term oral use.
Advantages Over Conventional Herbal Preparations
The innovation tackles long-standing challenges in herbal medicine by bringing scientific precision and consistency to Tulsi formulations. It offers better absorption, improved stability, and reliable quality across every batch. Designed to fit modern dosage forms, it bridges the gap between traditional herbal remedies and today’s healthcare standards preserving Tulsi’s natural benefits while ensuring safety and effectiveness.
According to the research team, the goal was to develop a modern phytopharmaceutical system that retains Tulsi’s natural therapeutic profile while ensuring the quality and reliability expected in regulated medicines.
Part of SwaLife Biotech’s PureHerbs Initiative
The development was carried out under SwaLife Biotech Pvt. Ltd., a company dedicated to advancing scientifically validated herbal formulations. Through its herbal wellness division, PureHerbs Capsules, SwaLife Biotech focuses on creating standardized natural supplements rooted in both Ayurvedic heritage and modern research.
The PureHerbs https://www.swalifebiotech.com/products.html range includes:
Neem: Detox and skin health support
Turmeric: Anti-inflammatory and immune balance
Wheatgrass: Rich source of chlorophyll and vitamins A, C, and E
Tulsi: Promotes respiratory and stress support
Moringa: Natural antioxidant and energy booster for sugar balance
Within this range, the Tulsi Capsules stand out for their enhanced extraction efficiency and antioxidant activity, aligning directly with the same scientific foundation as the new ultrasonic formulation. They represent the company’s vision to create evidence-based herbal solutions that cater to modern wellness needs.
A Step Toward Next-Generation Herbal Therapeutics
The development of this ultrasonic Tulsi formulation underscores India’s growing expertise in phytopharmaceutical innovation. By merging ancient plant knowledge with ultrasound-assisted technology, the researchers have laid the groundwork for safer, more effective, and globally competitive herbal therapies.
As awareness of natural chemopreventive strategies grows, this advancement highlights how modern science can elevate traditional medicinetransforming age-old remedies like Tulsi into next-generation healthcare solutions for oxidative stress, inflammation, and cancer prevention.
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